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KMID : 1138520110140040005
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Journal of Pharmacopuncture
2011 Volume.14 No. 4 p.5 ~ p.11
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Effects of Glycyrrhizae Radix Pharmacopuncture Intravenous Injection on Ischemia-Induced Acute Renal Failure in Rabbits
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김형철:Kim Hyeong-Cheol
김경호:Kim Gyoung-Ho/이금신:Lee Guem-San/김형우:Kim Hyung-Woo/임세현:Lim Se-Hyun/임지연:Lim Chi-Yeon/김영균:Kim Young-Kyun/조수인:Cho Su-In
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Abstract
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Objectives: The present study was undergone to determine whether Glycyrrhizae Radix pharmacopuncture intravenous injection exerts beneficial effect against the ischemia-induced acute renal failure in rabbits.
Methods: Rabbits were treated with Glycyrrhizae Radix pharmacopuncture via i.v., followed by renal ischemia/reperfusion. The fractional excretion of glucose and phosphate were measured and the malondialdehyde content was also determined. The morphological changes of cortical part of kidney also observed with light microscope.
Results: Renal ischemia/reperfusion caused increase of the fractional excretion of glucose and phosphate in ischemia-induced animals, which was prevented by Radix Glycyrrhizae extract treatment. Ischemia/reperfusion increased lipid peroxidation, which was prevented and morphological changes also altered by Radix Glycyrrhizae pharmacopuncture administration.
Conclusions: These results indicate that lipid peroxidation plays a critical role in ischemia-induced acute renal failure and Glycyrrhizae Radix pharmacopuncture exerts the protective effect against acute renal failure induced by renal ischemia/reperfusion.
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KEYWORD
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Glycyrrhizae Radix, pharmacopuncture, ischemia, renal failure
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